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123 results

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Page 1
The proteasome component PSMD14 drives myelomagenesis through a histone deubiquitinase activity.
He L, Yu C, Qin S, Zheng E, Liu X, Liu Y, Yu S, Liu Y, Dou X, Shang Z, Wang Y, Wang Y, Zhou X, Liu B, Zhong Y, Liu Z, Lu J, Sun L. He L, et al. Mol Cell. 2023 Nov 16;83(22):4000-4016.e6. doi: 10.1016/j.molcel.2023.10.019. Epub 2023 Nov 6. Mol Cell. 2023. PMID: 37935198
Here, we report that PSMD14 interacts with NSD2 on chromatin, independent of 19S RP. Functionally, PSMD14 acts as a histone H2AK119 deubiquitinase, facilitating NSD2-directed H3K36 dimethylation. ...Reciprocally, RELA transactivates PSMD14, forming a PSMD1 …
Here, we report that PSMD14 interacts with NSD2 on chromatin, independent of 19S RP. Functionally, PSMD14 acts as a histone H2 …
Deubiquitylase PSMD14 inhibits autophagy to promote ovarian cancer progression via stabilization of LRPPRC.
Zhao Z, Xu H, Wei Y, Sun L, Song Y. Zhao Z, et al. Biochim Biophys Acta Mol Basis Dis. 2023 Feb;1869(2):166594. doi: 10.1016/j.bbadis.2022.166594. Epub 2022 Nov 1. Biochim Biophys Acta Mol Basis Dis. 2023. PMID: 36328147 Free article.
TCGA data analysis shows that the autophagy level is suppressed, and the selective autophagy receptor SQSTM1/p62 is abnormally high expressed in ovarian cancer. We screen and identify that the deubiquitinase PSMD14 negatively regulates autophagy level. Functional studies s …
TCGA data analysis shows that the autophagy level is suppressed, and the selective autophagy receptor SQSTM1/p62 is abnormally high expresse …
Bioinformatics analysis and single-cell RNA sequencing: elucidating the ubiquitination pathways and key enzymes in lung adenocarcinoma.
Lu T, Xu R, Wang C, Zhou X, Parra-Medina R, Díaz-Peña R, Peng B, Zhang L. Lu T, et al. J Thorac Dis. 2023 Jul 31;15(7):3885-3907. doi: 10.21037/jtd-23-795. Epub 2023 Jul 28. J Thorac Dis. 2023. PMID: 37559628 Free PMC article.
PSMD14 expression and tumor stage were found to be independent prognostic factors, and interfering with PSMD14 expression reduced the malignant behavior of LUAD cells. PSMD14 was found to bind to AGR2 protein and reduce its ubiquitination, leading to increase …
PSMD14 expression and tumor stage were found to be independent prognostic factors, and interfering with PSMD14 expression redu …
PSMD14 stabilizes estrogen signaling and facilitates breast cancer progression via deubiquitinating ERalpha.
Yang P, Yang X, Wang D, Yang H, Li Z, Zhang C, Zhang S, Zhu J, Li X, Su P, Zhuang T. Yang P, et al. Oncogene. 2024 Jan;43(4):248-264. doi: 10.1038/s41388-023-02905-1. Epub 2023 Nov 29. Oncogene. 2024. PMID: 38017133 Free PMC article.
PSMD14 could facilitate breast cancer progression through ERalpha signaling in vitro and in vivo, while pharmaceutical inhibition of PSMD14 via Thiolutin could block the tumorigenesis in breast cancer. ...In general, we identified a novel positive feedback loop betw …
PSMD14 could facilitate breast cancer progression through ERalpha signaling in vitro and in vivo, while pharmaceutical inhibition of …
Novel insights into the non-canonical roles of PSMD14/POH1/Rpn11 in proteostasis and in the modulation of cancer progression.
Bustamante HA, Albornoz N, Morselli E, Soza A, Burgos PV. Bustamante HA, et al. Cell Signal. 2023 Jan;101:110490. doi: 10.1016/j.cellsig.2022.110490. Epub 2022 Oct 12. Cell Signal. 2023. PMID: 36241058
PSMD14/POH1/Rpn11 plays a crucial role in cellular homeostasis. PSMD14 is a structural subunit of the lid subcomplex of the proteasome 19S regulatory particle with constitutive deubiquitinase activity. ...During the assembly of the lid, activity of PSMD14 has …
PSMD14/POH1/Rpn11 plays a crucial role in cellular homeostasis. PSMD14 is a structural subunit of the lid subcomplex of the pr …
Targeting PSMD14 inhibits melanoma growth through SMAD3 stabilization.
Yokoyama S, Iwakami Y, Hang Z, Kin R, Zhou Y, Yasuta Y, Takahashi A, Hayakawa Y, Sakurai H. Yokoyama S, et al. Sci Rep. 2020 Nov 5;10(1):19214. doi: 10.1038/s41598-020-76373-y. Sci Rep. 2020. PMID: 33154524 Free PMC article.
After in silico analysis, TGF-beta signaling was identified as a negatively correlated gene set with PSMD14 expression. Although TGF-beta signaling is also related to the invasive phenotype of melanoma, PSMD14 knockdown suppressed melanoma migration and reduced SLUG …
After in silico analysis, TGF-beta signaling was identified as a negatively correlated gene set with PSMD14 expression. Although TGF- …
Deubiquitinating enzyme PSMD14 facilitates gastric carcinogenesis through stabilizing PTBP1.
Li J, Li Y, Xu F, Sun B, Yang L, Wang H. Li J, et al. Exp Cell Res. 2022 Jun 15;415(2):113148. doi: 10.1016/j.yexcr.2022.113148. Epub 2022 Apr 9. Exp Cell Res. 2022. PMID: 35405117

To investigate this issue, we first analyzed the PSMD14 expression via the TNMplot database and found that PSMD14 was up-regulated in GC tissues compared with the adjacent normal tissues (P < 0.01). ...PSMD14 was revealed to promote the deubiquitination an

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To investigate this issue, we first analyzed the PSMD14 expression via the TNMplot database and found that PSMD14 was up-regul …
Deubiquitinase PSMD14 promotes ovarian cancer progression by decreasing enzymatic activity of PKM2.
Sun T, Liu Z, Bi F, Yang Q. Sun T, et al. Mol Oncol. 2021 Dec;15(12):3639-3658. doi: 10.1002/1878-0261.13076. Epub 2021 Aug 25. Mol Oncol. 2021. PMID: 34382324 Free PMC article.
A high level of PSMD14 expression was related to poor survival in OV patients. Knockdown and overexpression experiments elucidated that PSMD14 stimulated OV cell proliferation, invasion, and migration in vitro. Repression of PSMD14 suppressed OV tumor growth …
A high level of PSMD14 expression was related to poor survival in OV patients. Knockdown and overexpression experiments elucidated th …
The function and mechanism of PSMD14 in promoting progression and resistance to anlotinib in osteosarcoma.
Liu Z, Wang X, Li C, Zhao R. Liu Z, et al. Cancer Cell Int. 2023 Dec 5;23(1):309. doi: 10.1186/s12935-023-03164-6. Cancer Cell Int. 2023. PMID: 38053170 Free PMC article.
Furthermore, a series of in vitro investigations were done to determine the effect of PSMD14 on anlotinib-resistant osteosarcoma cell lines. RESULTS: PSMD14 expression was elevated in osteosarcoma tissues compared to normal tissues. Overexpression of PSMD14 w …
Furthermore, a series of in vitro investigations were done to determine the effect of PSMD14 on anlotinib-resistant osteosarcoma cell …
Deubiquitinase PSMD14 enhances hepatocellular carcinoma growth and metastasis by stabilizing GRB2.
Lv J, Zhang S, Wu H, Lu J, Lu Y, Wang F, Zhao W, Zhan P, Lu J, Fang Q, Xie C, Yin Z. Lv J, et al. Cancer Lett. 2020 Jan 28;469:22-34. doi: 10.1016/j.canlet.2019.10.025. Epub 2019 Oct 18. Cancer Lett. 2020. PMID: 31634528
The present study aimed to reveal the functional significance of PSMD14 in HCC progression and the underlying mechanisms. We found that PSMD14 was significantly upregulated in HCC tissues. ...Mechanistically, we identified PSMD14 as a novel post-translational …
The present study aimed to reveal the functional significance of PSMD14 in HCC progression and the underlying mechanisms. We found th …
123 results